Structure of PDB 6nmi Chain E Binding Site BS02

Receptor Information

>6nmi Chain E (length=366) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGQVRLGMMRHLYVVV
DGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAE
KLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSR
EVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARET
GGTYHVILDESHYKELLTHHVSPPPASSSSECSLIRMGFPQHTIAAAAAA
AAAAAAAAAAAAAAAGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARS
YHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDC
DVFVHDSLHCCPGCIH

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6nmi Chain E Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6nmi The complete structure of the human TFIIH core complex.
Resolution	3.7 Å
Binding residue (original residue number in PDB)	C294 C308
Binding residue (residue number reindexed from 1)	C273 C287
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding

	Biological Process
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006351	DNA-templated transcription

	Cellular Component
GO:0000439	transcription factor TFIIH core complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6nmi, PDBe:6nmi, PDBj:6nmi
PDBsum	6nmi
PubMed	30860024
UniProt	Q13888\|TF2H2_HUMAN General transcription factor IIH subunit 2 (Gene Name=GTF2H2)

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