Structure of PDB 6mn5 Chain E Binding Site BS02

Receptor Information
>6mn5 Chain E (length=259) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QMMQYEWRKAELIGQLLNLGVTPGGVLLVHSSFRSVRPLEDGPLGLIEAL
RAALGPGGTLVMPSWSGLDDEPFDPATSPVTPDLGVVSDTFWRLPNVKRS
AHPFAFAAAGPQAEQIISDPLPLPPHSPASPVARVHELDGQVLLLGVGHD
ANTTLALAELMAKVPYGVPRHCTILQDGKLVRVDYLENDHCCERFALADR
WLKEKSLQKEGPVGHAFARLIRSRDIVATALGQLGRDPLIFLHPPEAGCE
ECDAARQSI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6mn5 Chain E Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6mn5 Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		H241 C247 C250
Binding residue
(residue number reindexed from 1)		H243 C249 C252
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.81: aminoglycoside N(3)-acetyltransferase.
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0046353 aminoglycoside 3-N-acetyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6mn5, PDBe:6mn5, PDBj:6mn5
PDBsum6mn5
PubMed35338238
UniProtQ306W4

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