Structure of PDB 6l3u Chain E Binding Site BS02

Receptor Information
>6l3u Chain E (length=201) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEF
VCHTQQPGCKAACFDAFHPLSPLRFWVFQVILVAVPSALYMGFTLYHVIW
HWELSGGAGSLRLLWAYVAQLGARLVLEGAALGLQYHLYGFQMPSSFACR
REPCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLLGLGRWWR
T
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6l3u Chain E Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6l3u Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		D66 P70
Binding residue
(residue number reindexed from 1)		D65 P69
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005243 gap junction channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Biological Process
GO:0007154 cell communication
GO:0007267 cell-cell signaling
GO:0007605 sensory perception of sound
GO:0042552 myelination
GO:0055085 transmembrane transport
GO:0086053 AV node cell to bundle of His cell communication by electrical coupling
Cellular Component
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0005922 connexin complex
GO:0043209 myelin sheath

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6l3u, PDBe:6l3u, PDBj:6l3u
PDBsum6l3u
PubMed32923625
UniProtQ8NFK1|CXG3_HUMAN Gap junction gamma-3 protein (Gene Name=GJC3)

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