Structure of PDB 6jlz Chain E Binding Site BS02

Receptor Information
>6jlz Chain E (length=409) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQSIPIEFQAVVFAGFGNSLYPLTGSDALPKALLPIGNKPMLHYPLYWLE
AAGFTSAILICMEEAEAHINAWLRSGYEGHMRIHVEAPTILDDSKSSADA
LRAVSHLIKNDFVCLSCDSIVGLPPYTVLDKFRLDNPSALAVYSPVLKYE
HITSQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRV
TLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLVKCQYQKSFTV
RENIQRFLSSPSSQEIKINALIAKDGIICSRANNLPNYFELNKCIAKLTP
EQRLVDVTVSERALVGADCMVNEGTTIKDNSNIKKSIIGKNCVIGKGVVV
SNSILMDNIVVEDGVRLESCIVASGAQIGAKSKLRECEIGVDHRVEAGRI
ARGERLVDM
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain6jlz Chain E Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6jlz Structural basis for eIF2B inhibition in integrated stress response.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		N49 R263
Binding residue
(residue number reindexed from 1)		N18 R232
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009058 biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0032045 guanyl-nucleotide exchange factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jlz, PDBe:6jlz, PDBj:6jlz
PDBsum6jlz
PubMed31048492
UniProtP56288|EI2BG_SCHPO Translation initiation factor eIF2B subunit gamma (Gene Name=tif223)

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