Structure of PDB 6fga Chain E Binding Site BS02

Receptor Information
>6fga Chain E (length=79) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPV
CRQRFLLKNLRPNRQLANMVNNLKEISQE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6fga Chain E Residue 102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6fga E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
Resolution2.82 Å
Binding residue
(original residue number in PDB)		C16 C19 C36 C39
Binding residue
(residue number reindexed from 1)		C13 C16 C33 C36
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6fga, PDBe:6fga, PDBj:6fga
PDBsum6fga
PubMed31160341
UniProtP19474|RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (Gene Name=TRIM21)

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