Structure of PDB 6bbn Chain E Binding Site BS02

Receptor Information

>6bbn Chain E (length=378) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SNCVKEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRG
SLDYRPLPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPK
QKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCF
AYGQTGSGKTHTMGGDSKGIYALAARDVFLMLKKPNYKKLELQVYATFFE
IYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGN
SCRTSAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQT
RLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRT
CMIATISPGMASCENTLNTLRYANRVKE

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

6bbn Chain E Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6bbn Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.
Resolution	3.514 Å
Binding residue (original residue number in PDB)	T320 S433 D457
Binding residue (residue number reindexed from 1)	T160 S259 D283
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding

	Biological Process
GO:0007018	microtubule-based movement

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Molecular Function

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Biological Process

External links

PDB	RCSB:6bbn, PDBe:6bbn, PDBj:6bbn
PDBsum	6bbn
PubMed	29980677
UniProt	O00139\|KIF2A_HUMAN Kinesin-like protein KIF2A (Gene Name=KIF2A)

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