Structure of PDB 6a4b Chain E Binding Site BS02

Receptor Information

>6a4b Chain E (length=217) Species: 10090 (Mus musculus)

PRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSGSLVLP
RVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQGF
LSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALRGL
DRAHSRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELLAW
ADEQARSWAHIEPMYVP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6a4b Chain E Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6a4b Structural insights into the duplex DNA processing of TREX2
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): D14 D123
• Binding residue (residue number reindexed from 1): D10 D119
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.11.2: exodeoxyribonuclease III.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003676 nucleic acid binding
• GO:0004527 exonuclease activity
• GO:0008296 3'-5'-DNA exonuclease activity
• GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
• GO:0008408 3'-5' exonuclease activity
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006281 DNA repair

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:6a4b, PDBe:6a4b, PDBj:6a4b
• PDBsum: 6a4b
• PubMed: 30357414
• UniProt: Q9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)