Structure of PDB 5ubq Chain E Binding Site BS02

Receptor Information

>5ubq Chain E (length=441) Species: 5911 (Tetrahymena thermophila)

MREVISIHVGQGGIQVGNACWELFCLEHGIQPDGQMPSDKTIGGGDDAFN
TFFSETGAGKHVPRAVFLDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAA
NNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNSVGGGTGSGLG
SLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSILSTHSLLEHTDV
AVMLDNEAIYDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNV
DITEFQTNLVPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNSAFEPAN
MMAKCDPRHGKYMACSMMYRGDVVPKDVNASIATIKTKRTIQFVDWCPTG
FKVGINYQPPTVVPGGDLAKVMRAVCMISNSTAIAEVFSRLDHKFDLMYA
KRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIETAE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5ubq Chain E Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ubq Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins.
• Resolution: 5.7 Å
• Binding residue (original residue number in PDB): D69 E71
• Binding residue (residue number reindexed from 1): D69 E71
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:5ubq, PDBe:5ubq, PDBj:5ubq
• PDBsum: 5ubq
• PubMed: 28462916
• UniProt: P41351|TBA_TETTH Tubulin alpha chain