Structure of PDB 5sxu Chain E Binding Site BS02

Receptor Information
>5sxu Chain E (length=308) Species: 198628 (Dickeya dadantii 3937) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPVDVSVSIFINKIYGVNTLEQTYKVDGYIVAQWTGKPRKTPGDKPLIVE
NTQIERWINNGLWVPALEFINVVGSPDTGNKRLMLFPDGRVIYNARFLGS
FSNDMDFRLFPFDRQQFVLELEPFSYNNQQLRFSDIQVYTENIDNEEIDE
WWIRGKASTHISDIRYDHLSSVQPNQNEFSRITVRIDAVRNPSYYLWSFI
LPLGLIIAASWSVFWLESFSERLQTSFTLMLTVVAYAFYTSNILPRLPYT
TVIDQMIIAGYGSIFAAILLIIFAHHRQANGVEDDLLIQRCRLAFPLGFL
AIGCVLVI
Ligand information
Ligand IDBRJ
InChIInChI=1S/C2H5BrO/c3-1-2-4/h4H,1-2H2
InChIKeyLDLCZOVUSADOIV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04BrCCO
CACTVS 3.341OCCBr
OpenEye OEToolkits 1.5.0C(CBr)O
FormulaC2 H5 Br O
Name2-BROMOETHANOL
ChEMBLCHEMBL468583
DrugBank
ZINCZINC000004978447
PDB chain5sxu Chain E Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5sxu Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		P74 L76 Y102
Binding residue
(residue number reindexed from 1)		P65 L67 Y93
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0007165 signal transduction
GO:0034220 monoatomic ion transmembrane transport
GO:0042391 regulation of membrane potential
Cellular Component
GO:0016020 membrane
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5sxu, PDBe:5sxu, PDBj:5sxu
PDBsum5sxu
PubMed27916519
UniProtE0SJQ4

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