Structure of PDB 5n2v Chain E Binding Site BS02

Receptor Information

>5n2v Chain E (length=223) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SFTNATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFYEDFIRA
QNDQLPSLGLRVFSAKLFAHCPLLWKWSKVHEEAFDDFLRYKTRIPVRGA
IMLDMSMQQCVLVKGWKASSGWGFPKGKIDKDESDVDCAIREVYEETGFD
CSSRINPNEFIDMTIRGQNVRLYIIPGISLDTRFESRTRKEISKIEWHNL
MDLPTFYMVIPFLAPLKKWIKKR

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

5n2v Chain E Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5n2v Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme.
Resolution	3.1 Å
Binding residue (original residue number in PDB)	K127 E147
Binding residue (residue number reindexed from 1)	K126 E146
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.-.-.-

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0140933	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

	Biological Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function

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Biological Process

External links

PDB	RCSB:5n2v, PDBe:5n2v, PDBj:5n2v
PDBsum	5n2v
PubMed	28533364
UniProt	O13828\|DCP2_SCHPO mRNA decapping complex subunit 2 (Gene Name=dcp2)

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