Structure of PDB 5iuk Chain E Binding Site BS02

Receptor Information
>5iuk Chain E (length=206) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKERERLEEKLEDANERIAELVKLEERQRIARDLEDTLGQKLSLIGLKSD
LARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSGIRLKDELINIKQI
LEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQAKTCRVD
IQQLWKEVVITVSDDGTFKGSKGHGLLGMRERLEFANGSLHIDTENGTKL
TMAIPN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5iuk Chain E Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5iuk Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E289 N293
Binding residue
(residue number reindexed from 1)		E133 N137
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.13.3: histidine kinase.
Gene Ontology
Molecular Function
GO:0000155 phosphorelay sensor kinase activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000160 phosphorelay signal transduction system
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5iuk, PDBe:5iuk, PDBj:5iuk
PDBsum5iuk
PubMed27938660
UniProtO34757|DESK_BACSU Sensor histidine kinase DesK (Gene Name=desK)

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