Structure of PDB 5h9e Chain E Binding Site BS02

Receptor Information
>5h9e Chain E (length=354) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKS
GYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKSVD
EAEKISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIR
VNLQQGVDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFT
AVDDLQEQGSAHLGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIA
THVVHMLATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAK
DGFLQPSIQAFNQYWDRVANGYGLNGAAAQFSLTAQVKQMPTLEQLKSWV
RNNG
Ligand information
>5h9e Chain N (length=40) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctgttggcaagccaggatctgaacaataccgtcatcgagc
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5h9e Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
Resolution3.21 Å
Binding residue
(original residue number in PDB)		D109 A110 M166 T168 G210 S211 H213 L214
Binding residue
(residue number reindexed from 1)		D108 A109 M165 T167 G209 S210 H212 L213
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5h9e, PDBe:5h9e, PDBj:5h9e
PDBsum5h9e
PubMed26863189
UniProtQ46899|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

[Back to BioLiP]