Structure of PDB 5flv Chain E Binding Site BS02

Receptor Information
>5flv Chain E (length=227) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYK
SKRQRQIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPK
TKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAH
WMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKASTHVFPETA
FIAVTSYQNHKITQLKIENNPFAKGFR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5flv Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
Resolution3.005 Å
Binding residue
(original residue number in PDB)		Y161 Q186 R189 Y190 R1081 R1082 K1159 Y1217 T1223 I1227 N1230 F1232 F1236
Binding residue
(residue number reindexed from 1)		Y20 Q45 R48 Y49 R84 R85 K162 Y207 T213 I217 N220 F222 F226
Binding affinityPDBbind-CN: Kd~50nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5flv, PDBe:5flv, PDBj:5flv
PDBsum5flv
PubMed26875865
UniProtP42582;
P70326

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