Structure of PDB 5f6k Chain E Binding Site BS02

Receptor Information
>5f6k Chain E (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTI
IRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPN
CVAEVVTFERGHKIIISSSRRIQKGEELCYDYKIPCHCGAVNCRKWMN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5f6k Chain E Residue 5001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f6k Structural basis for activity regulation of MLL family methyltransferases.
Resolution2.411 Å
Binding residue
(original residue number in PDB)		C4899 C4901 C4906
Binding residue
(residue number reindexed from 1)		C136 C138 C143
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y4800 I4876
Catalytic site (residue number reindexed from 1) Y46 I122
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:5f6k, PDBe:5f6k, PDBj:5f6k
PDBsum5f6k
PubMed26886794
UniProtQ8NEZ4|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)

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