Structure of PDB 5ei9 Chain E Binding Site BS02

Receptor Information

>5ei9 Chain E (length=111) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EKPYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRH
QRTHTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNK
SHLLRHQRTHT

Ligand information

>5ei9 Chain B (length=21) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tggcctccctagccacgtgga

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5ei9 Structural basis for human PRDM9 action at recombination hot spots.
Resolution	1.921 Å
Binding residue (original residue number in PDB)	R736 S760 H761 Y775 D786 K787 S788 K815 S816 L819 R823
Binding residue (residue number reindexed from 1)	R21 S45 H46 Y60 D71 K72 S73 K100 S101 L104 R108
Binding affinity	PDBbind-CN: Kd=36nM

Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.

External links

PDB	RCSB:5ei9, PDBe:5ei9, PDBj:5ei9
PDBsum	5ei9
PubMed	26833727
UniProt	Q9NQV7\|PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (Gene Name=PRDM9)

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