Structure of PDB 5eh2 Chain E Binding Site BS02

Receptor Information

>5eh2 Chain E (length=110) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KPYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRHQ
RTHTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNKS
HLLRHQRTHT

Ligand information

>5eh2 Chain B (length=21) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tgaggcctccctagccacgtg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5eh2 Structural basis for human PRDM9 action at recombination hot spots.
Resolution	2.05 Å
Binding residue (original residue number in PDB)	Y719 K731 S732 K759 S760 Y775 K787 S788 K815 S816 L819 R823
Binding residue (residue number reindexed from 1)	Y3 K15 S16 K43 S44 Y59 K71 S72 K99 S100 L103 R107
Binding affinity	PDBbind-CN: Kd=28nM

Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.

External links

PDB	RCSB:5eh2, PDBe:5eh2, PDBj:5eh2
PDBsum	5eh2
PubMed	26833727
UniProt	Q9NQV7\|PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (Gene Name=PRDM9)

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