Structure of PDB 5e24 Chain E Binding Site BS02

Receptor Information

>5e24 Chain E (length=424) Species: 7227 (Drosophila melanogaster)

HIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIY
LFGSGWTRRYEEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCA
AKTLFISDSDKRKHFMLSVKMFYGNGHDIGVFNSKRIKVISKPSKKKQSL
KNADLCIASGTNVALFNRLRSQTVSTRYLHVEGGHFHASSTQWGAFTIHL
LDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMALL
EADDPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMIND
GACWTIISTDKAEYQFYEGMGPVASPVTPVPIVNSLNLNGGGDVAMLELS
GDNFTPHLQVWFGDVEAETMYRCTETLLCVVPEISQFRGEWLWVRQPTQV
PISLVRNDGIIYATGLTFTYTPEP

Ligand information

>5e24 Chain H (length=15)

ttactgtgggaaaga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5e24 Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster.
• Resolution: 2.14 Å
• Binding residue (original residue number in PDB): K138 R139 F140 K240 K243 R266 R268 K359
• Binding residue (residue number reindexed from 1): K40 R41 F42 K142 K145 R168 R170 K261

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:5e24, PDBe:5e24, PDBj:5e24
• PDBsum: 5e24
• PubMed: 27404588
• UniProt: P28159|SUH_DROME Suppressor of hairless protein (Gene Name=Su(H))