Structure of PDB 5ak9 Chain E Binding Site BS02

Receptor Information

>5ak9 Chain E (length=183) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ENVSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITAKSENLIKQHIAP
LMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNMR
EQIAFIKGLYVAEGDMTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHLD
DHRHGVYVLNISLRDRIKFVHTILSSHLNPLPP

Ligand information

>5ak9 Chain D (length=25) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgcgccggaacttacccggcaaggc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5ak9 Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
Resolution	2.601 Å
Binding residue (original residue number in PDB)	S179 H181 L182 N183
Binding residue (residue number reindexed from 1)	S175 H177 L178 N179
Binding affinity	PDBbind-CN: Kd=0.3nM

Enzymatic activity

Enzyme Commision number

3.1.-.-

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity

	Biological Process
GO:0006314	intron homing
GO:0016539	intein-mediated protein splicing

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Molecular Function

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Biological Process

External links

PDB	RCSB:5ak9, PDBe:5ak9, PDBj:5ak9
PDBsum	5ak9
PubMed	26045557
UniProt	P21505\|DMO1_DESMO Homing endonuclease I-DmoI

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