Structure of PDB 4skn Chain E Binding Site BS02

Receptor Information
>4skn Chain E (length=223) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEFFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQM
CDIKDVKVVILGQNPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDI
EDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVS
WLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPRSVYRGFFGC
RHFSKTNELLQKSGKKPIDWKEL
Ligand information
Receptor-Ligand Complex Structure
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PDB4skn A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R272 Y275
Binding residue
(residue number reindexed from 1)		R191 Y194
Enzymatic activity
Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0004844 uracil DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4skn, PDBe:4skn, PDBj:4skn
PDBsum4skn
PubMed8900285
UniProtP13051|UNG_HUMAN Uracil-DNA glycosylase (Gene Name=UNG)

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