Structure of PDB 4r89 Chain E Binding Site BS02

Receptor Information
>4r89 Chain E (length=537) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALLVRM
VMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFGLLK
KDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPVYEL
RCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFRLRA
DVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLFQFA
QHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALAREASC
APESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSEPCS
VEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHPFHS
APADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSPFVY
WELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWPAQR
RYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4r89 Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1
Resolution4.002 Å
Binding residue
(original residue number in PDB)		Y21 R65 R69 Y81 V191
Binding residue
(residue number reindexed from 1)		Y5 R49 R53 Y65 V175
Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4r89, PDBe:4r89, PDBj:4r89
PDBsum4r89
PubMed25319828
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

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