Structure of PDB 4n0o Chain E Binding Site BS02

Receptor Information
>4n0o Chain E (length=396) Species: 299386 (Equine arteritis virus Bucyrus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVCTVCGAAPVAKSACGGWFCGNCVPYHAGHCHTTSLFACGHDIMYRSTY
CTMCEGSPKQMVPKVPHPILDHLLCHIDYGSKEELTLVVADGTTSPPGRY
KVGHKVVAVVADVGGNIVFGCPGSHIVPLQDTLKGVVVNKALKNAAASEY
VEGPPGSGKTFHLVKDVLAVVGSATLVVPTHASMLDCINKLKQAGADPYF
VVPKYTVLDFPRPGSGNITVRLPQVGTSEGETFVDEVAYFSPVDLARILT
QGRVKGYGDLNQLGCVGPASVPRNLWLRHFVSLEPLRVCHRFGAAVCDLI
KGIYPYYEPAPHTTKVVFVPNPDFEKGVVITAYHKDRGLGHRTIDSIQGC
TFPVVTLRLPTPQSLTRPRAVVAVTRASQELYIYDPFDQLSGLLKF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4n0o Chain E Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4n0o Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		H29 H32 C33
Binding residue
(residue number reindexed from 1)		H28 H31 C32
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.21.-
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4n0o, PDBe:4n0o, PDBj:4n0o
PDBsum4n0o
PubMed24369429
UniProtP19811|RPOA_EAVBU Replicase polyprotein 1ab (Gene Name=rep)

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