Structure of PDB 4k50 Chain E Binding Site BS02

Receptor Information
>4k50 Chain E (length=460) Species: 31708 (rhinovirus A16) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQIQISKHVKDVGLPSIHTPTKTKLQPSVFYDIFPGSKEPAVLTEKDPRL
KVDFDSALFSKYKGNTECSLNEHIQVAVAHYSAQLATLDIDPQPIAMEDS
VFGMDGLEALDLNTSAGYPYVTLGIKKKDLINNKTKDISKLKLALDKYDV
DLPMITFLKDELRKKDKIAAGKTRVIEASSINDTILFRTVYGNLFSKFHL
NPGVVTGCAVGCDPETFWSKIPLMLDGDCIMAFDYTNYDGSIHPIWFKAL
GMVLDNLSFNPTLINRLCNSKHIFKSTYYEVEGGVPSGCSGTSIFNSMIN
NIIIRTLVLDAYKHIDLDKLKIIAYGDDVIFSYKYKLDMEAIAKEGQKYG
LTITPADKSSEFKELDYGNVTFLKRGFRQDDKYKFLIHPTFPVEEIYESI
RWTKKPSQMQEHVLSLCHLMWHNGPEIYKDFETKIRSVSAGRALYIPPYE
LLRHEWYEKF
Ligand information
Receptor-Ligand Complex Structure
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PDB4k50 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		N113 N133 K134 Y325 D327 D328 L373 R375 F391 E395 S399 K404 Q408 H412 S415
Binding residue
(residue number reindexed from 1)		N113 N133 K134 Y325 D327 D328 L373 R375 F391 E395 S399 K404 Q408 H412 S415
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4k50, PDBe:4k50, PDBj:4k50
PDBsum4k50
PubMed23667424
UniProtQ82122|POLG_HRV16 Genome polyprotein

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