Structure of PDB 4ig9 Chain E Binding Site BS02

Receptor Information
>4ig9 Chain E (length=270) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYA
RLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIA
LSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCE
AVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKD
EVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGD
CDVIINELCHRLGGEYAKLC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ig9 Structural and Functional Analysis of Human SIRT1.
Resolution2.64 Å
Binding residue
(original residue number in PDB)		K236 N241 T242 I243 D475 E477 L478 L479 I485 E488 H491
Binding residue
(residue number reindexed from 1)		K5 N10 T11 I12 D244 E246 L247 L248 I254 E257 H260
Enzymatic activity
Catalytic site (original residue number in PDB) P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1) P40 D41 F42 R43 N115 D117 H132
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4ig9, PDBe:4ig9, PDBj:4ig9
PDBsum4ig9
PubMed24120939
UniProtQ96EB6|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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