Structure of PDB 4i5n Chain E Binding Site BS02

Receptor Information
>4i5n Chain E (length=357) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSSQSIPTFYFPRGRPSVNVDAVISKIESTFARFPHERATMDDMGLVAKA
CGCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLL
MSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFY
AVNRSWSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYC
KFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRGRKVQKEGK
ISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQC
RRLDSMAIEALPFQDCLCQMLDLVKPRTEGKITLQDLKRCKLANVFFDTF
FNIEKYL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4i5n Chain E Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4i5n Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D327 D329 D331 L333
Binding residue
(residue number reindexed from 1)		D206 D208 D210 L212
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:4i5n, PDBe:4i5n, PDBj:4i5n
PDBsum4i5n
PubMed23752926
UniProtQ99741;
Q9Y5P8|P2R3B_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (Gene Name=PPP2R3B)

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