Structure of PDB 3w11 Chain E Binding Site BS02
Receptor Information
>3w11 Chain E (length=288) Species:
9606
(Homo sapiens) [
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GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEE
CGDICNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSEC
LGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDL
HHKQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPK
Ligand information
>3w11 Chain F (length=11) Species:
9606
(Homo sapiens) [
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FEDYLHNVVFV
Receptor-Ligand Complex Structure
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PDB
3w11
How insulin engages its primary binding site on the insulin receptor
Resolution
3.9 Å
Binding residue
(original residue number in PDB)
R14 L36 F64 F88 F89 Y91 F96 R118
Binding residue
(residue number reindexed from 1)
R10 L32 F60 F84 F85 Y87 F92 R114
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:3w11
,
PDBe:3w11
,
PDBj:3w11
PDBsum
3w11
PubMed
23302862
UniProt
P06213
|INSR_HUMAN Insulin receptor (Gene Name=INSR)
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