Structure of PDB 3ol7 Chain E Binding Site BS02

Receptor Information
>3ol7 Chain E (length=461) Species: 12080 (Poliovirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRL
KTDFEEAIFSKYVGNKITEVDEYMKEAVDHYAGQLMSLDINTEQMCLEDA
MYGTDGLEALDLSTSAGYPYVAMGKKKRDILNKQTRDTKEMQKLLDTYGI
NLPLVTYVKDELRSKTKVEQGKSRLIEASSLNDSVAMRMAFGNLYAAFHK
NPGVITGSAVGCDPDLFWSKIPVLMEEKLFAFDYTGYDASLSPAWFEALK
MVLEKIGFGDRVDYIDYLNHSHHLYKNKTYCVKGGMPSGCSGTSIFNSMI
NNLIIRTLLLKTYKGIDLDHLKMIAYGDDVIASYPHEVDASLLAQSGKDY
GLTMTPADKSATFETVTWENVTFLKRFFRADEKYPFLIHPVMPMKEIHES
IRWTKDPRNTQDHVRSLCLLAWHNGEEEYNKFLAKIRSVPIGRALDLPEY
STLYRRWLDSF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ol7 Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K133 K159 R174 D238 S288 S294 Y326 D328 K375 S400 N409 H413
Binding residue
(residue number reindexed from 1)		K133 K159 R174 D238 S288 S294 Y326 D328 K375 S400 N409 H413
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3ol7, PDBe:3ol7, PDBj:3ol7
PDBsum3ol7
PubMed21148772
UniProtP03300|POLG_POL1M Genome polyprotein

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