Structure of PDB 3hkj Chain E Binding Site BS02

Receptor Information
>3hkj Chain E (length=249) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSAGAGCDRGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hkj Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		F34 R67 R73 T74 R75 Y76 I82
Binding residue
(residue number reindexed from 1)		F19 R62 R68 T69 R70 Y71 I78
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E194 G195 D196 S197 G198
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3hkj, PDBe:3hkj, PDBj:3hkj
PDBsum3hkj
PubMed19586901
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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