Structure of PDB 3azh Chain E Binding Site BS02

Receptor Information

>3azh Chain E (length=99) Species: 9606 (Homo sapiens)

KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQS
SAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPQDIQLARRIRGERA

Ligand information

>3azh Chain J (length=145)

tcaatatccacctgcagattctaccaaaagtgtatttggaaactgctcca
tcaaaaggcatgttcagctgaattcagctgaacatgccttttgatggagc
agtttccaaatacacttttggtagaatctgcaggtggatattgat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3azh Comprehensive Structural Analysis of Mutant Nucleosomes Containing Lysine to Glutamine (KQ) Substitutions in the H3 and H4 Histone-Fold Domains
• Resolution: 3.49 Å
• Binding residue (original residue number in PDB): H39 Y41 R42 P43 T45 R63 R72 R83 F84 Q85 S86 V117 T118 M120
• Binding residue (residue number reindexed from 1): H3 Y5 R6 P7 T9 R27 R36 R47 F48 Q49 S50 V81 T82 M84

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0045296 cadherin binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0006334 nucleosome assembly
• GO:0010467 gene expression
• GO:0032200 telomere organization
• GO:0040029 epigenetic regulation of gene expression

Cellular Component

• GO:0000786 nucleosome
• GO:0005576 extracellular region
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0016020 membrane
• GO:0032991 protein-containing complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:3azh, PDBe:3azh, PDBj:3azh
• PDBsum: 3azh
• PubMed: 21812398
• UniProt: P68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)