Structure of PDB 3aoe Chain E Binding Site BS02

Receptor Information
>3aoe Chain E (length=416) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAYRPPEDPGLWDTYLEWLERALKVAGVHPTTLEYLAHPKRLVTLSLPVV
MDDGKVRIFQGYRVVHDIARGPAKGGVRLDPGVTLGQTAGLAAWMTLKAA
VYDLPFGGAAGGIAVDPKGLSPQELERLVRRYTAELVGLIGPDSDILGPD
LGADQQVMAWIMDTYSMTVGSTVPGVVTGKPHALGGSEGRDDAAGLGALL
VLEALAKRRGLDLRGARVVVQGLGQVGAAVALHAERLGMRVVAVATSMGG
MYAPEGLDVAEVLSAYEATGSLPRLDLAPEEVFGLEAEVLVLAAREGALD
GDRARQVQAQAVVEVANFGLNPEAEAYLLGKGALVVPDLLSGGGGLLASY
LEWVQDLNMFFWSPEEVRERFETRVARVVDAVCRRAERGGLDLRMGALAL
ALERLDEATRLRGVYP
Ligand information
Ligand IDLEU
InChIInChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKeyROHFNLRQFUQHCH-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)C[C@@H](C(=O)O)N
CACTVS 3.341CC(C)C[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CC(C)CC(C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CC(C)C
CACTVS 3.341CC(C)C[CH](N)C(O)=O
FormulaC6 H13 N O2
NameLEUCINE
ChEMBLCHEMBL291962
DrugBankDB00149
ZINCZINC000003645145
PDB chain3aoe Chain C Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3aoe An unique allosteric regulation revealed by hetero-hexameric glutamate dehydrogenase from Thermus thermophilus
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D166 M170
Binding residue
(residue number reindexed from 1)		D163 M167
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) A113 D153
Catalytic site (residue number reindexed from 1) A110 D150
Enzyme Commision number 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].
Gene Ontology
Molecular Function
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological Process
GO:0006520 amino acid metabolic process
GO:0006538 glutamate catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3aoe, PDBe:3aoe, PDBj:3aoe
PDBsum3aoe
PubMed
UniProtQ72IC0

[Back to BioLiP]