Structure of PDB 2zp7 Chain E Binding Site BS02

Receptor Information
>2zp7 Chain E (length=391) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SWSEAFGKGAGRIQASTIRELLKLTQRPGILSFAGGLPAPELFPKEEAAE
AAARILREKGEVALQYSPTEGYAPLRAFVAEWIGVRPEEVLITTGSQQAL
DLVGKVFLDEGSPVLLEAPSYMGAIQAFRLQGPRFLTVPAGEEGPDLDAL
EEVLKRERPRFLYLIPSFQNPTGGLTPLPARKRLLQMVMERGLVVVEDDA
YRELYFGEARLPSLFELAREAGYPGVIYLGSFSKVLSPGLRVAFAVAHPE
ALQKLVQAKQGADLHTPMLNQMLVHELLKEGFSERLERVRRVYREKAQAM
LHALDREVPKEVRYTRPKGGMFVWMELPKGLSAEGLFRRALEENVAFVPG
GPFFANGGGENTLRLSYATLDREGIAEGVRRLGRALKGLLA
Ligand information
Ligand IDLEU
InChIInChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKeyROHFNLRQFUQHCH-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)C[C@@H](C(=O)O)N
CACTVS 3.341CC(C)C[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CC(C)CC(C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CC(C)C
CACTVS 3.341CC(C)C[CH](N)C(O)=O
FormulaC6 H13 N O2
NameLEUCINE
ChEMBLCHEMBL291962
DrugBankDB00149
ZINCZINC000003645145
PDB chain2zp7 Chain E Residue 700 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2zp7 Mechanism for multiple-substrates recognition of alpha-aminoadipate aminotransferase from Thermus thermophilus
Resolution2.26 Å
Binding residue
(original residue number in PDB)		I22 G40 N174 R368
Binding residue
(residue number reindexed from 1)		I18 G36 N170 R364
Annotation score2
Enzymatic activity
Enzyme Commision number 2.6.1.39: 2-aminoadipate transaminase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0009058 biosynthetic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:1901605 alpha-amino acid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2zp7, PDBe:2zp7, PDBj:2zp7
PDBsum2zp7
PubMed18831049
UniProtQ72LL6|LYSN_THET2 2-aminoadipate transaminase (Gene Name=lysN)

[Back to BioLiP]