Structure of PDB 2yev Chain E Binding Site BS02

Receptor Information

>2yev Chain E (length=319) Species: 300852 (Thermus thermophilus HB8)

AHRVAITHPGGSFNQEVAFLFPWVYFFSFLIFLVVAGSLAYVTWKFRARP
EDQEEPPQIHGNDRLEVVWTLIPLAIVFVLFGLTAKALIQVNRPIPGAMK
VEVTGYQFWWDFHYPELGLRNSNELVLPAGVPVELEITSKDVIHSFWVPG
LAGKRDAIPGQTTRISFEPKEPGLYYGFCAELCGASHARMLFRVVVLPKE
EFDRFVEAAKASPAPVADERGQQVFQQNCAACHGVARSMPPAVIGPELGL
WGNRTSLGAGIVENTPENLKAWIRDPAGMKPGVKMPGFPQLSEEDLDALV
RYLEGLKVEGFDFGALPKF

Ligand information

• Ligand ID: CUA
• InChI: InChI=1S/2Cu
• InChIKey: ALKZAGKDWUSJED-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Cu][Cu]
• Formula: Cu2
• Name: DINUCLEAR COPPER ION
• PDB chain: 2yev Chain E Residue 585

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2yev Structural Insights Into Electron Transfer in Caa3-Type Cytochrome Oxidases.
• Resolution: 2.36 Å
• Binding residue (original residue number in PDB): H162 C197 E199 C201 H205 M208
• Binding residue (residue number reindexed from 1): H144 C179 E181 C183 H187 M190
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0022900 electron transport chain
• GO:0042773 ATP synthesis coupled electron transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:2yev, PDBe:2yev, PDBj:2yev
• PDBsum: 2yev
• PubMed: 22763450
• UniProt: Q5SLI2