Structure of PDB 2ayi Chain E Binding Site BS02

Receptor Information

>2ayi Chain E (length=397) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AFKRNLEKLAELAIRVGLNLEKGQEVIATAPIEAVDFVRLLAEKAYREGA
SLFTVIYGDQELARKRLALAPEEGLDKAPAWLYEGMARAFREGAARLAVS
GSDPKALEGLPPEKVGRAQKANARAYKPALEAITEFVTNWTIVPFAHPGW
ARAVFPGLPEEEAVRRLWEAIFQATPIAAWEAHNRALHEKVAYLNARRFH
ALHFKGPGTDLVVGLAEGHLWQGGATATKGGRLCNPNLPTEEVFTAPHRE
RVEGVVRASRPLALGGTLVEGIFARFERGFAVEVRAEKGEEVLRRLLDTD
EGARRLGEVALVPADNPIAKTGLVFFDTLFDENAASHIAFGQAYQENLEG
GEAFRKRGGNESLVHVDWMIGSEEMDVDGLYEDGTRTPLMRRGRWVV

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2ayi Chain E Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2ayi Substrate Access to the Active Sites in Aminopeptidase T, a Representative of a New Metallopeptidase Clan.
Resolution	3.7 Å
Binding residue (original residue number in PDB)	E250 E316 H345
Binding residue (residue number reindexed from 1)	E242 E308 H337
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.11.-

Gene Ontology

	Molecular Function
GO:0004177	aminopeptidase activity
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:2ayi, PDBe:2ayi, PDBj:2ayi
PDBsum	2ayi
PubMed	16242715
UniProt	P42778\|AMPT_THET8 Aminopeptidase T (Gene Name=TTHA1152)

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