Structure of PDB 1r8q Chain E Binding Site BS02

Receptor Information
>1r8q Chain E (length=191) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEG
LNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG
EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSYSVIMLNTDLHNPNVR
DKMGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1r8q Chain E Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1r8q Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
Resolution1.86 Å
Binding residue
(original residue number in PDB)		H127 D131
Binding residue
(residue number reindexed from 1)		H72 D76
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0032012 regulation of ARF protein signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1r8q, PDBe:1r8q, PDBj:1r8q
PDBsum1r8q
PubMed14654833
UniProtQ99418|CYH2_HUMAN Cytohesin-2 (Gene Name=CYTH2)

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