Structure of PDB 148l Chain E Binding Site BS02
Receptor Information
>148l Chain E (length=162) Species:
10665
(Tequatrovirus T4) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
MNIFEMLRIDEGLRLKIYKDTEGYYEIGIGHLLTKSPSLNAAKSELDKAI
GRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALI
NMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVI
TTFRTGTWDAYK
Ligand information
Ligand ID
MUB
InChI
InChI=1S/C11H19NO8/c1-4(10(16)17)19-9-7(12-5(2)14)11(18)20-6(3-13)8(9)15/h4,6-9,11,13,15,18H,3H2,1-2H3,(H,12,14)(H,16,17)/t4-,6-,7-,8-,9-,11+/m1/s1
InChIKey
MNLRQHMNZILYPY-MDMHTWEWSA-N
SMILES
Software
SMILES
CACTVS 3.341
C[CH](O[CH]1[CH](O)[CH](CO)O[CH](O)[CH]1NC(C)=O)C(O)=O
ACDLabs 10.04
O=C(O)C(OC1C(O)C(OC(O)C1NC(=O)C)CO)C
OpenEye OEToolkits 1.5.0
CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C
CACTVS 3.341
C[C@@H](O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O)[C@@H]1NC(C)=O)C(O)=O
OpenEye OEToolkits 1.5.0
C[C@H](C(=O)O)O[C@@H]1[C@H]([C@H](O[C@@H]([C@H]1O)CO)O)NC(=O)C
Formula
C11 H19 N O8
Name
N-acetyl-alpha-muramic acid;
N-acetyl-muramic acid;
N-ACETYLMURAMIC ACID
ChEMBL
CHEMBL1234516
DrugBank
ZINC
ZINC000003861769
PDB chain
148l Chain A Residue 1 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
148l
A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
E11 D20 Y24 E26 G30 L32 F104 Q105
Binding residue
(residue number reindexed from 1)
E11 D20 Y24 E26 G30 L32 F104 Q105
Annotation score
4
Enzymatic activity
Enzyme Commision number
3.2.1.17
: lysozyme.
Gene Ontology
Molecular Function
GO:0003796
lysozyme activity
GO:0016798
hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009253
peptidoglycan catabolic process
GO:0016998
cell wall macromolecule catabolic process
GO:0031640
killing of cells of another organism
GO:0042742
defense response to bacterium
GO:0044659
viral release from host cell by cytolysis
Cellular Component
GO:0030430
host cell cytoplasm
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:148l
,
PDBe:148l
,
PDBj:148l
PDBsum
148l
PubMed
8266098
UniProt
P00720
|ENLYS_BPT4 Endolysin (Gene Name=E)
[
Back to BioLiP
]