Structure of PDB 4w2f Chain DZ Binding Site BS02

Receptor Information

>4w2f Chain DZ (length=160) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MEYRLKAYYREGEKPSALRRAGKLPGVMYNRHLNRKVYVDLVEFDKVFRQ
ASIHHVIVLELPDGQSLPTLVRQVNLDKRRRRPEHVDFFVLSDEPVEMYV
PLRFVGHRDILVKVSPRNIPEFIEVDVSGLEIGDSLHASDLKLPPGVELA
VSPEETIAAV

Ligand information

>4w2f Chain DB (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacg
gaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccuggga
gaguaggucggugcggggga

.<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>..
.....>>>.>>>>>>>>>>.

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4w2f Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	R10 K14 R19 V27 Y29 N30 R31 N34 R72 Q73 R79 E84 H85 D87 F89
Binding residue (residue number reindexed from 1)	R10 K14 R19 V27 Y29 N30 R31 N34 R72 Q73 R79 E84 H85 D87 F89

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:4w2f, PDBe:4w2f, PDBj:4w2f
PDBsum	4w2f
PubMed	25306919
UniProt	Q5SHZ1\|RL25_THET8 Large ribosomal subunit protein bL25 (Gene Name=rplY)

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