Structure of PDB 7zx0 Chain DDD Binding Site BS02

Receptor Information
>7zx0 Chain DDD (length=633) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIDDGFPIKGCDDTLV
VGLAVCWGGRDAYYFSLQKVPPSLDPSLTLKDRMWYLQSCLRKESDKECS
VVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTS
FLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLN
SLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLD
AIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALHP
LPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRI
TFTEPNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLELR
ILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICY
GIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRD
GFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVN
IQKQLETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQI
VKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zx0 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		T2179 K2181 R2201 N2205 K2209 R2241 Q2250 N2251 V2252 P2253 R2254 R2315 H2539
Binding residue
(residue number reindexed from 1)		T287 K289 R309 N313 K317 R349 Q358 N359 V360 P361 R362 R378 H582
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7zx0, PDBe:7zx0, PDBj:7zx0
PDBsum7zx0
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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