Structure of PDB 7q5w Chain DDD Binding Site BS02

Receptor Information
>7q5w Chain DDD (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA
HGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP
FNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEK
LIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALC
LLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLT
VPCQKIG
Ligand information
>7q5w Chain LLL (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ESPYQELQGQRSDVYSDLNT
Receptor-Ligand Complex Structure
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PDB7q5w The tandem SH2 domains of SYK
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H62 Y64 G98
Binding residue
(residue number reindexed from 1)		H56 Y58 G92
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:7q5w, PDBe:7q5w, PDBj:7q5w
PDBsum7q5w
PubMed
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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