Structure of PDB 7ahz Chain DDD Binding Site BS02

Receptor Information
>7ahz Chain DDD (length=56) Species: 8364 (Xenopus tropicalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPCVICQTRPKNGCIVHGRTGHLMACYTCAKKLKKRNKPCPVCREPIQMI
VLTYFS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ahz Chain DDD Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ahz Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
Resolution1.82 Å
Binding residue
(original residue number in PDB)		H443 H448 C466 C469
Binding residue
(residue number reindexed from 1)		H17 H22 C40 C43
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0042802 identical protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ahz, PDBe:7ahz, PDBj:7ahz
PDBsum7ahz
PubMed33450248
UniProtQ6P3Q9

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