Structure of PDB 7pub Chain DA Binding Site BS02

Receptor Information
>7pub Chain DA (length=1552) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFKYATKLQHDEMRQPYYIHEKRYGIFSNERNIAKARRGLPFITPLYTKH
MNLWDTDTDASNNRFFRGYYYGQRELHQLLGRPHSLEATNADGSNDLSTY
EANTSQLYKGIPRPAITNLHYEPAWRYTLYQAGAHGAQLSNPRSPFTAKV
LGDELMQVRDIKSVEHCKAWFDRLQYLINLHYEAVGDIGEFKSRHTRHVH
EFFVAFHDALSSLDFRDTYLFDQFKAVRPPELSDLFGIFLEMEANYVHED
YCPRCSLPYSTTRYCGEGDVDTPFRKHRGRWAPHQKWGREWYDVVARRAE
ALWYRATEDPYFGTPQHTQRQAEALLKVYVQAKQRGKAIDFMNKLRGSVE
YLTGDITITTVMQESYDALLDTTPHPHLLTNGFTLESDAAKYTGEVNKAP
LSPLQFRIDMEMNKYRRQQKEEGVVRVPPALWRLDTSAIVPYKVDSKTRR
IVNWREVKEGIEKSFLSVGLPKEAYTGNEWREMLYLHDVIANREAKAAVL
EQQQKLDREKLKARERASLKGEKSSNSASNGIGIIFPDKDGYQVFFVDEA
SLRPFGIGASGTLFKAVARVYPSPAAVPYDDPVHGKQFLIDTTDETCHLF
GGFEHGDRLLLRAKSEEEVIVMGVSTEGSDAERMLCAMHVDTGKQRERGI
VFLGTDCIDIRERWESVRYAASAYVKGRVTLLESQRTAREEFMGQVVGIR
DGVLFVQWRLLKGGGSVLDRSVAVPIGDSTQVRELFVETKVLGVEPLQSP
PSWRTPFRNDFAEERLKELQRAPFKREKYVSLIQGKYTPKVKKFGYTQHT
TVDDFETKEYKDRLLSKQFFQNPQAFEVVPDRNERSVQFGGKWEYQRTHG
LPTVDRNELENGWSEVEPISDGEMKVIEQALRDISGPRPGNFVKPPSKTK
SLQLSESWWEPLGYGWEQHNEEQKALCDVTEQRLIDGSNLPFGGKLPPFG
TSYGMGERMRAIIEDYSKGFGLGPHGHSPTHDTIHYNTLNAEGERVRDLG
YTDALGRLFSEKLGDRDVHQWAVESCADGEADVRQLLLSLHEWRERGRPP
SLLLANVLSKYLEEEIAAFNKGIPENAPKLQLETSDGTLAHSGSGGSRSG
TMWADVDPTTFALHQASQSTRSTRCDEPFILHLVKRAKLGECVTNFTDTA
YIAHLESSVINEFHLALTKLVGKGISPTLLAQKTGQLHRGSVRVGGNVVP
FVKSRELSRLLERMGLTSESIAVITRGLANCPEQESVGDDFAVPVSLILS
WDQNEDKMVVHVLEELSLRNDGLVMDIQYAIRENKKNRRLRWEFVTTLLP
VFGGNEAKVEQLYSDYCDGKYVPNITVAVEAFIAFLHNATQHPETYSASD
YFDIDDGKSSTASGTGDQPSAGQYTTLKLLDPLEGPFVFDNVKVEYIQTV
ERFRRHGIRAGPVMAPATGFIAANCKSLNYFTRRQEEVVYVTNDSDQGLR
RSLENSAYHKTIAANPALQYLLKARRGAALVETFNRFFYRTMPMLNFYQN
VLKHYSETIQPLRQAAKSSTRGLARALESERSAAMEEFRRNSERYWRNII
EG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7pub Chain DA Residue 2000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pub Mitoribosomal small subunit maturation involves formation of initiation-like complexes.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		C291 C304 H323
Binding residue
(residue number reindexed from 1)		C252 C265 H284
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit

View graph for
Cellular Component
External links
PDB RCSB:7pub, PDBe:7pub, PDBj:7pub
PDBsum7pub
PubMed35042777
UniProtQ57UJ2

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