Structure of PDB 6hiv Chain DA Binding Site BS02

Receptor Information
>6hiv Chain DA (length=1557) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFKYATKLQHDEMRQPYYIHEKRYGIFSNERNIAKARRGLPFITPLYTKH
MNLWDTDTDASNNRFFRGYYYGQRELHQLLGRPHSLEATNADGSNDLSTY
EANTSQLYKGIPRPAITNLHYEPAWRYTLYQAGAHGAQLSNPRSPFTAKV
LGDELMQVRDIKSVEHCKAWFDRLQYLINLHYEAVGDIGEFKSRHTRHVH
EFFVAFHDALSSLDFRDTYLFDQFKAVRPPELSDLFGIFLEMEANYVHED
YCPRCSLPYSTTRYCGEGDVDTPFRKHRGRWAPHQKWGREWYDVVARRAE
ALWYRATEDPYFGTPQHTQRQAEALLKVYVQAKQRGKAIDFMNKLRGSVE
YLTGDITITTVMQESYDALLDTTPHPHLLTNGFTLESDAAKYTGEVNKAP
LSPLQFRIDMEMNKYRRQQKEEGVVRVPPALWRLDTSAIVPYKVDSKTRR
IVNWREVKEGIEKSFLSVGLPKEAYTGNEWREMLYLHDVIANREAKAAVL
EQQQKLDREKLKARERASLKGEKSSNSASNGIGIIFPDKDGYQVFFVDEA
SLRPFGIGASGTLFKAVARVYPSPAAVPYDDPVHGKQFLIDTTDETCHLF
GGFEHGDRLLLRAKSDEEEEVIVMGVSTEGSDAERMLCAMHVDTGKQRER
GIVFLGTDCIDIRERWESVRYAASAYVKGRVTLLESQRTAREEFMGQVVG
IRDGVLFVQWRLLKGGGSVLDRSVAVPIGDSTQVRELFVETKVLGVEPLQ
SPPSWRTPFRNDFAEERLKELQRAPFKREKYVSLIQGKYTPKVKKFGYTQ
HTTVDDFETKEYKDRLLSKQFFQNPQAFEVVPDRHERSVQFGGKWEYQRT
HGLPTVDRNELENGWSEVEPISDGEMKVIEQALRDISGPRPGNFVKPPSK
TKSLQLSESWWEPLGYGWEQHNEEQKALCDVTEQRLIDGSNLPFGGKLPP
FGTSYGMGERMRAIIEDYSKGFGLGPHGHSPTHDTIHYNTLNAEGERVRD
LGYTDALGRLFSEKLGDRDVHQWAVESCADGEADVRQLLLSLHEWRERGR
PPSLLLANVLSKYLEEEIAAFNKGIPENAPKLQLETSDGTLAHSGSGGSR
SGTMWADVDPTTFALHQASQSTRSTRCDEPFILHLVKRAKLGECVTNFTD
TAYIAHLESSVINEFHLALTKLVGKGISPTLLAQKTGQLHRGSVRVGGNV
VPFVKSRELSRLLERMGLTSESIAVITRGLANCPEQESVGDDFAVPVSLI
LSWDGPGQNEDKMVVHVLEELSLRNDGLVMDIQYAIRENKKNRRLRWEFV
TTLLPVFGGNEAKVEQLYSDYCDGKYVPNITVAVEAFIAFLHNATQHPET
YSASDYFDIDDGKSSTASGTGDQPSAGQYTTLKLLDPLEGPFVFDNVKVE
YIQTVERFRRHGIRAGPVMAPATGFIAANCKSLNYFTRRQEEVVYVTNDS
DQGLRRSLENSAYHKTIAANPALQYLLKARRGAALVETFNRFFYRTMPML
NFYQNVLKHYSETIQPLRQAAKSSTRGLARALESERSAAMEEFRRNSERY
WRNIIEG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6hiv Chain DA Residue 1801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6hiv Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Resolution7.8 Å
Binding residue
(original residue number in PDB)		C291 C304 H323
Binding residue
(residue number reindexed from 1)		C252 C265 H284
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0005739 mitochondrion
GO:0005763 mitochondrial small ribosomal subunit

View graph for
Cellular Component
External links
PDB RCSB:6hiv, PDBe:6hiv, PDBj:6hiv
PDBsum6hiv
PubMed30213880
UniProtQ57UJ2

[Back to BioLiP]