Structure of PDB 6t59 Chain D3 Binding Site BS02

Receptor Information
>6t59 Chain D3 (length=293) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMI
VRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTG
LLLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLAR
TTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQ
NVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPV
YEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAA
Ligand information
>6t59 Chain 74 (length=120) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcuu
<<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..
>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>..
..>>>>>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB6t59 TTC5 mediates autoregulation of tubulin via mRNA degradation.
Resolution3.11 Å
Binding residue
(original residue number in PDB)		K10 F13 K14 Y16 V18 F20 R21 R22 R24 T28 Y30 R33 I52 R54 T56 N57 R58 I61 I69 E70 G71 D72 M73 I74 Y79 N94 R152 T155 N157 K158 V204 Y207 Q222 F223 S224 Q225 Y226 Y253 K255 K256 R259 V261 W266 N267 R268 P269 K270 M271 L273 K276 K277 R279 K283 K284
Binding residue
(residue number reindexed from 1)		K8 F11 K12 Y14 V16 F18 R19 R20 R22 T26 Y28 R31 I50 R52 T54 N55 R56 I59 I67 E68 G69 D70 M71 I72 Y77 N92 R150 T153 N155 K156 V202 Y205 Q220 F221 S222 Q223 Y224 Y251 K253 K254 R257 V259 W264 N265 R266 P267 K268 M269 L271 K274 K275 R277 K281 K282
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t59, PDBe:6t59, PDBj:6t59
PDBsum6t59
PubMed31727855
UniProtP19949|RL5_RABIT Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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