Structure of PDB 7ls1 Chain D2 Binding Site BS02

Receptor Information
>7ls1 Chain D2 (length=251) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHD
PGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNV
LPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLP
SGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRG
VAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKT
V
Ligand information
>7ls1 Chain m2 (length=1723) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugaccccccuucccggggggg
gaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgca
cgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuu
cgaugguagucgccgugccuaccauggugaccacgggugacggggaauca
ggguucgauuccggagagggagccugagaaacggcuaccacauccaagga
aggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacg
aaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucc
acuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguua
aaaagcucguaguuggaucuugggagcgggcguccccgcccucucggcgg
ggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccga
gccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuau
uuuguugguuuucggaacugaggccaugauuaagagggacggccgggggc
auucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacgga
ccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaag
ucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacga
ugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuu
ccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcug
aaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggc
uuaauuugacucaacacgggaaaccucacccggcccggacacggacagga
uugacagauugauagcucuuucucgauuccgugggugguggugcauggcc
guucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgag
acucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccccc
aacuucuuagagggacaaguggcguucagccacccgagauugagcaauaa
caggucugugaugcccuuagauguccggggcugcacgcgcgcuacacuga
cuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguug
aaccccauucgugauggggaucggggauugcaauuauuccccaugaacga
ggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugc
ccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugagg
cccucggaucggccccgccggggugcccuggcggagcgcugagaagacgg
ucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguag
gugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<......<<..<......<<<.
<<<........<<....<<..........>>...>>.........<<...
.....<<<.<..........<<<...........<<.....<<.......
......>>......>>.........<<<<<..<<<<<<<....>>>>>>>
.>.>>>><<..<<<<<...<......>..>>>>>......>>....<<<.
<<<<......>>>>>>>.....>>>.......>.>>>.<<<....<<<..
.....<<<<.........>>>.>..>>>......>>>...<<<.<<<<..
..>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>
.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>
>.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..
<...........>..>>.........<<<<<.((...<.<<<<.....<<
..))>>.......>>>>>>>>>>...>>>>>.>>>.........<.<((.
....<.<<...<<<..........................<<.<......
......>>>....<<<<<.<.......<<...<.......>..<<.....
.....>>...>>......>.>>>..>>.........<.<..<<<<<<<..
.............>>>>>>>..>.>..........<<<<<.<.<...<<<
<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>..
.....<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<
<<<<<<...<...<<<<.........>>>>...>>>>>>>>.........
.<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>.
...<<.))>>...>>.....>>>.>.>.<<.......<<<<....>>>>.
....>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<
......<<........>>..........<<<<<.<....<<<<<<.....
..<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<
<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>...
.<<<...<...<<<...<<<<<<<<<<<<.......>>>>.>>>>.....
>>>>...>>>..>.....<<<<<.....>>>>>........>>>....>>
>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<
.<<<........<.......<<<<<<<<....>>>>>>>>....>.....
....>>>.>>............<<<<<..........>>>>>........
...>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>
>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<...<
<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>
>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<
<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ls1 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R247 G248 T249
Binding residue
(residue number reindexed from 1)		R246 G247 T248
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0140236 translation at presynapse
GO:0140242 translation at postsynapse
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0014069 postsynaptic density
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0045202 synapse
GO:0098793 presynapse
GO:0098794 postsynapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ls1, PDBe:7ls1, PDBj:7ls1
PDBsum7ls1
PubMed34815424
UniProtP62918|RL8_MOUSE Large ribosomal subunit protein uL2 (Gene Name=Rpl8)

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