Structure of PDB 8apf Chain D1 Binding Site BS02

Receptor Information
>8apf Chain D1 (length=488) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VADHKGRVGHVSQVIGAVVDVHFADGVPPVLTALDVVDKLGRDEPLTLEI
VQHLDAHTGRCIAMQTTDLLKLKAKVVSTGGNISVPVGRETLGRIFNVLG
DAIDQRGPVGEKLRMPIHAVAPKLADQAAEDAVLTTGIKVIDLILPYCKG
GKIGLFGGAGVGKTVIIMELINNVAKGHGGFSVFAGVGERTREGTDLYLE
MMQSKVIDLKGESKCVLVYGQMNEPPGARARVAQSALTMAEYFRDVEGQD
VLLFIDNIFRFTQANSEVSALLGRIPAAVGYQPTLAEDLGQLQERITSTT
KGSITSVQAVYVPADDITDPAPATTFSHLDATTVLDRAVAESGIYPAVNP
LECASRIMDPDVISVDHYNVAQDVVQMLTKYRELQDIIAVLGIDELSEED
KLIVDRARKLVKFLSQPFQVAEVFTGMTGHYVQLDDTIDSFSGLLMGTYD
QVPEMAFYMVGGINSVLEKAKKMAEEAAELEKMRRARV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8apf Chain D1 Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8apf An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		T190 E215
Binding residue
(residue number reindexed from 1)		T164 E189
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.2.2: H(+)-transporting two-sector ATPase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015986 proton motive force-driven ATP synthesis
GO:0042776 proton motive force-driven mitochondrial ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8apf, PDBe:8apf, PDBj:8apf
PDBsum8apf
PubMed36220811
UniProtQ9GPE9|ATPB_TRYBB ATP synthase subunit beta, mitochondrial (Gene Name=Tb427.03.1380)

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