Structure of PDB 8zb8 Chain D Binding Site BS02

Receptor Information

>8zb8 Chain D (length=421) Species: 9823 (Sus scrofa)

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLLTVPELTQQMFDSKNMMAACDPRHGRY
LTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTE
AESNMNDLVSEYQQYQDATAD

Ligand information

• Ligand ID: A1D8I
• InChI: InChI=1S/C17H16N4S/c1-11-18-14-7-9-22-16(14)17(19-11)21(3)13-4-5-15-12(10-13)6-8-20(15)2/h4-10H,1-3H3
• InChIKey: WTDOSEGYWYJIAO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: Cc1nc2ccsc2c(n1)N(C)c3ccc4c(c3)ccn4C
  CACTVS 3.385: Cn1ccc2cc(ccc12)N(C)c3nc(C)nc4ccsc34
• Formula: C17 H16 N4 S
• Name: ~{N},2-dimethyl-~{N}-(1-methylindol-5-yl)thieno[3,2-d]pyrimidin-4-amine
• PDB chain: 8zb8 Chain D Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8zb8 Crystal structure of T2R-TTL-DPP21 complex
• Resolution: 2.94 Å
• Binding residue (original residue number in PDB): C239 A248 K252 L253 N256 M257 A314 N348 K350
• Binding residue (residue number reindexed from 1): C239 A248 K252 L253 N256 M257 A304 N338 K340
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0005525 GTP binding

Biological Process

• GO:0007010 cytoskeleton organization

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:8zb8, PDBe:8zb8, PDBj:8zb8
• PDBsum: 8zb8
• UniProt: A0A8D1UIR5