Structure of PDB 8v6o Chain D Binding Site BS02

Receptor Information
>8v6o Chain D (length=640) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASD
TGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQ
TALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPL
ALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDF
VKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIK
EKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNR
HEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREE
EAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSI
LSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYT
RGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDN
KDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTF
VLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFR
MGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPV
Ligand information
Ligand IDFZ4
InChIInChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChIKeyBLZVCIGGICSWIG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
OpenEye OEToolkits 2.0.6		B(c1ccccc1)(c2ccccc2)OCCN
CACTVS 3.385NCCOB(c1ccccc1)c2ccccc2
FormulaC14 H16 B N O
Name2-aminoethyl diphenylborinate
ChEMBLCHEMBL169233
DrugBank
ZINCZINC000169743034
PDB chain8v6o Chain D Residue 910 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8v6o TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site
Resolution2.83 Å
Binding residue
(original residue number in PDB)		S444 W493 M706
Binding residue
(residue number reindexed from 1)		S328 W377 M590
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v6o, PDBe:8v6o, PDBj:8v6o
PDBsum8v6o
PubMed38691614
UniProtQ8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (Gene Name=TRPV3)

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