Structure of PDB 8t2r Chain D Binding Site BS02

Receptor Information
>8t2r Chain D (length=388) Species: 39491 (Agathobacter rectalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNLMEQILSSDNLNRAYLQVVRNKGAEGVDGMKYTELKEHLAKNGETIKG
QLRTRKYKPQPGVPTVTDRFIQQAIAQVLTPIYEEQFHDHSYGFRPNRCA
QQAILTALNIMNDGNDWIVDIDLEKFFDTVNHDKLMTLIGRTIKDGDVIS
IVRKYLVSGNLSPLLANIMLNELDKEMEKRGLNFVRYADDCIIMVGSEMS
ANRVMRNISRFIEEKLGLKVNMTKSKVDRPSGLKYLGFGFYFDPRAHQFK
AKPHAKSVAKFKKRMKELTCRSWGVSNSYKVEKLNQLIRGWINYFKIGSM
KTLCKELDSRIRYRLRMCIWKQWKTPQNQEKNLVKLGIDRNTARRVAYTG
KRIAYVCNKGAVNVAISNKRLASFGLISMLDYYIEKCV
Ligand information
>8t2r Chain B (length=545) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugcgcgccaugggcgcgcucuaacggguguaagucccgaacaugccc
agguagugggaaauguauagccgaacagcaagggugucuacugugaggug
gaaucugaaggaagcuguaagcgaaucucugguccgacggacagaaaucg
cauauaaggcuaggcuucgagugauaagcuggcaaagaacagugaagucu
aauaacuaccaguagaagcagaguaaaugcggcggauauauggagagaaa
gagcgugcaccuuaagcguggaggucucacagaggugccuaguaacaacg
aacugugagaagucagccgagcccauaguagugaagaagucucuguaaug
gggauggagcgaaggggcgaacaaucaaucaugucucguauugcagaaau
gacaacaucugccguaaccaaucggguaaaagguggucaaaucaagcgag
acggaaagguaaguugauugaaccgccguauacggaaccguacguacggu
ggugugagaggucggaauuucgaaauucuuccuacucgauugaau
.....<<<<<...<<<<<<<<<<<..<<<<.......>>>>.<<<<.<<<
..(((((>>>..>>>>...<<....<<<<..<<<<.<<<<<<....>>>>
>>>>>>.......>>>>...>>...<<<<<<<<<<<...........<<<
<<......<<<..<<<<<....<<<..<<<<........>>>>...>>>.
....))))).....>>>>>..>>>...>>>>>>>>>>...>>>>>>...>
>>>>>>>>.>>....>>>>>...<<<<<<<<<<<<..>>>.<......>.
..>>>>>>>>..>....<..<<<<......<<......<<<<<<.....>
>>>>>...>>....>>>>>..<<<<<<<<..<...<<<<.<<<<.<<..<
<<<..<<<<..<<<........>>>......>>>>>>>>..>>..>>>>.
>>>>...>....>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>
>>>..<<<<<<..<<<<<<<..>>>>>>>.>>>.>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8t2r Structural insights into intron catalysis and dynamics during splicing
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R58 D152 T156 R160 S169 R172 K173 R217 L219 V232 G233 S234 M236 S237 R240 V241 R243 N244 K300 K303 R308 S309 G311 R347 Y350 R351 M354 K358 K361 R389 A391
Binding residue
(residue number reindexed from 1)		R55 D133 T137 R141 S150 R153 K154 R180 L182 V195 G196 S197 M199 S200 R203 V204 R206 N207 K263 K266 R271 S272 G274 R310 Y313 R314 M317 K321 K324 R352 A354
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003964 RNA-directed DNA polymerase activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006974 DNA damage response

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8t2r, PDBe:8t2r, PDBj:8t2r
PDBsum8t2r
PubMed37993708
UniProtA0A173ZME3

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