Structure of PDB 8qqs Chain D Binding Site BS02

Receptor Information
>8qqs Chain D (length=740) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEII
VTIHADNSVSVQDDGRGISVVNALSQKLELVIQREGKIHRQIYEHGVPQA
TGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGK
EDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGF
QENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATG
DDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYLL
ENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQE
RDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKML
SSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLT
FFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALD
GATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKAMLKELIYQ
PTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLFEP
IVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGER
RQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRM
LRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qqs Structural basis of DNA crossover capture by E. coli DNA gyrase
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E424 D426 S427 K447 G448 R457 K460 D502 K740
Binding residue
(residue number reindexed from 1)		E362 D364 S365 K385 G386 R395 K398 D440 K678
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0034335 DNA negative supercoiling activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-templated DNA replication
GO:0006265 DNA topological change
GO:0006351 DNA-templated transcription
GO:0009410 response to xenobiotic stimulus
GO:0046677 response to antibiotic
GO:0051276 chromosome organization
Cellular Component
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qqs, PDBe:8qqs, PDBj:8qqs
PDBsum8qqs
PubMed38603484
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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