Structure of PDB 8oia Chain D Binding Site BS02

Receptor Information
>8oia Chain D (length=335) Species: 5722 (Trichomonas vaginalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIKCALDCDPGHDDLAMIMLAVYSPKLDVQYISTTHGNQTVNKTYQNARR
TLNLIKRADKIPVYRGYSKPLTRESVASGLGGVDWSEIDRTMPRNPALDI
LGYKDESELRPDDFFKHLHRLVSAAEDKFDIISTGSETNIAQYLLAYPED
AKKIRMTTMAGNFMIVGNIMPFAEFNVLIDPEAISNILQSGVDYTFAAPL
DITHTVLVTEKVINDIKAATEPYSPKFTEMIIKLLFFFKDTYRDVFGFID
PPLHDPVAAFHLIAPEWFEHVRCHVDIETKGEYTYGCCCTNLILKPTKIV
KPDNATVCLKLKEGGHDAFWNQMITVWGEIAKEIG
Ligand information
Ligand IDRIB
InChIInChI=1S/C5H10O5/c6-1-2-3(7)4(8)5(9)10-2/h2-9H,1H2/t2-,3-,4-,5+/m1/s1
InChIKeyHMFHBZSHGGEWLO-AIHAYLRMSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@H]([C@H](O1)O)O)O)O
ACDLabs 10.04OC1C(OC(O)C1O)CO
FormulaC5 H10 O5
Namealpha-D-ribofuranose;
alpha-D-ribose;
D-ribose;
ribose
ChEMBLCHEMBL606078
DrugBank
ZINCZINC000003860714
PDB chain8oia Chain D Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8oia A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D14 M167 E182 H262 D263
Binding residue
(residue number reindexed from 1)		D13 M159 E174 H254 D255
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008477 purine nucleosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006152 purine nucleoside catabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oia, PDBe:8oia, PDBj:8oia
PDBsum8oia
PubMed37482279
UniProtA2FTT0

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