Structure of PDB 8ka0 Chain D Binding Site BS02

PDB	8ka0 Crystal structure of Vibrio vulnificus RID-dependent transforming NADase domain (RDTND)/calmodulin-binding domain of Rho inactivation domain (RID-CBD) complexed with Ca2+-bound calmodulin and a nicotinamide adenine dinucleotide (NAD+)
Resolution	2.35 Å
Binding residue (original residue number in PDB)	D94 D96 N98 Y100
Binding residue (residue number reindexed from 1)	D90 D92 N94 Y96
Annotation score	4

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0010856	adenylate cyclase activator activity
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0031432	titin binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0044325	transmembrane transporter binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0072542	protein phosphatase activator activity

	Biological Process
GO:0000086	G2/M transition of mitotic cell cycle
GO:0002027	regulation of heart rate
GO:0005513	detection of calcium ion
GO:0007186	G protein-coupled receptor signaling pathway
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0021762	substantia nigra development
GO:0031954	positive regulation of protein autophosphorylation
GO:0032465	regulation of cytokinesis
GO:0050848	regulation of calcium-mediated signaling
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592	response to calcium ion
GO:0055117	regulation of cardiac muscle contraction
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0140238	presynaptic endocytosis
GO:1901020	negative regulation of calcium ion transmembrane transporter activity
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1905913	negative regulation of calcium ion export across plasma membrane

	Cellular Component
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030017	sarcomere
GO:0031982	vesicle
GO:0032991	protein-containing complex
GO:0034704	calcium channel complex
GO:0043209	myelin sheath
GO:0044305	calyx of Held
GO:0097225	sperm midpiece
GO:0099523	presynaptic cytosol
GO:1902494	catalytic complex

External links

PDB	RCSB:8ka0, PDBe:8ka0, PDBj:8ka0
PDBsum	8ka0
PubMed	39043696
UniProt	P0DP24\|CALM2_HUMAN Calmodulin-2 (Gene Name=CALM2)