Structure of PDB 8hmb Chain D Binding Site BS02

Receptor Information
>8hmb Chain D (length=1253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVE
YLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAIFD
VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY
AIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVC
KPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW
IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE
DLKGYLDWITQAEDIWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIAS
EHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDC
FVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVAS
LLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFP
QSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYI
LLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLFRLQCHRIVNDTIFT
NLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTLEIILKMT
AYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVL
RPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKG
KLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLA
AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIII
AFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYI
PKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNI
LNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSEV
NPAEHTSITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI
VMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEA
WQDIMLACMPGKKCAPESEPCGSSFAVFYFISFYMLCAFLIINLFVAVIM
DNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQP
CPHRVACKRLVSNATLFALVRTALRIKTEGNLEQANEELRAIIKKLLDQV
VPP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8hmb Chain D Residue 2314 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hmb Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		E363 E706 E1135
Binding residue
(residue number reindexed from 1)		E231 E513 E812
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0030315 T-tubule
GO:0030425 dendrite
GO:0034702 monoatomic ion channel complex
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0098839 postsynaptic density membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hmb, PDBe:8hmb, PDBj:8hmb
PDBsum8hmb
PubMed38555290
UniProtA0A0A0MSA1

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